생명공학연구소 8차 세미나 안내(16:00~)
2014.11.03생명공학연구소2279
- 일시 : 2014.11.05
생명공학연구소에서는 다음과 같이 세미나를 개최하고자 하오니 교수님 및 학생 여러분들의 많은 참석 바랍니다.
◈ 주 제 : Toward understanding of plant aging and senescence
◈ 연 사 : 임평옥 (Pyung Ok Lim) 교수
◈ 소 속 : Department of New Biology, DGIST
◈ 일 시 : 2014년 11월 05일 (수) 오후4시
◈ 장 소 : 영남대학교 생명공학관 333호
< Abstract >
In the annual plants, aging and senescence is regarded as a life history strategy, a process of functional transition of cells, organs, and organisms, although it includes some wear and tear processes inevitably. We are trying to understand how and why plants age and die at genetic, molecular and systems level. Through extensive genetic screening of mutants with increased life span of leaves in Arabidopsis, we identified various molecular mechanisms that control leaf aging and senescence. We previously identified the trifurcate feed forward pathway for age-dependent cell death involving EIN2, ORE1, and miR164 (Science, 2009) in Arabidopsis, which revealed fundamental characteristics of network-level control of plant aging and senescence. Recently, we have further characterized new genetic components of the trifurcate feed-forward pathway. The data together with previous results provide insight into how the EIN2-mediated senescence signaling pathway coordinates global gene expression during leaf senescence via a gene regulatory network involving EIN3 and NAC TFs. We are now expanding the NAC regulatory pathway involved in control of senescence through comprehensive systems approaches.Senescence can be better understood by examining the shift of functional and regulatory molecular networks throughout life history. We thus performed next generation sequencing (NGS) for several stages of a leaf from an early age to death to examine the life history of Arabidopsis leaf. We used directional total RNA-seq, mRNA-seq, and smRNA-seq to provide comprehensive multi-dimensional transcriptomes of Arabidopsis leaf during the entire lifespan, including diverse RNA, and organellar transcripts. Leaf lifespan programs were accompanied by global changes of coding and non-coding RNAs, and also distinct, yet coordinated age-dependent changes in the nuclear, mitochondrial, and chloroplast. Through these studies, we aim to understand age-dependent change of molecular network, its integration into aging and death, and evolution of aging and death and to provide a plausible clue to reprogram aging process.
영남대학교 생명공학연구소장
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