[생명공학연구소] 2017년도 제1차 세미나 개최
- 일시 : 2017.03.06
[생명공학연구소] 2017년도 제 1차 세미나 개최
생명공학연구소에서는 다음과 같이 세미나를 개최하고자 하오니 교수님들과 학생 여러분의 많은 참여 바랍니다.
주제 :: Small RNAs Make a Big Difference: p53-regulated microRNA family mediates cell reprogramming and stem cell potency
연사 :: 최용진 박사 (University of California at Berkeley, USA)
일시 :: 2017년 3월 6일 (월) 오후 4시 30분 ~ 6시 15분
장소 :: 생명공학관 310호
<초록>
Mouse zygotes and early blastomeres have totipotent cell fate potential, generating both embryonic and extraembryonic cell lineages during normal development. This totipotent potential is gradually restricted during development, with the first cell fate specification event being completed by the blastocyst stage. Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) exhibit a pluripotent potential similar to that of the epiblast in blastocysts, efficiently generating all embryonic cell types but rarely contributing to extraembryonic lineages in the placenta and yolk sac. Experimentally, ESCs and iPSCs can be induced into cells with expanded developmental potential, albeit with low efficiency. Such pluripotent stem cells are characterized by their bidirectional developmental potential (contributing to both embryonic and extraembryonic lineages) and thei! r strong induction of the MuERV-L (MERVL) ! endogenous retroviruses (ERVs), both of which are features of totipotent two-cell (2C) blastomeres. The low efficiency in generating bipotential ESCs reflects the existence of multiple cellular and molecular impediments that restrict the pluripotent cell fate potential.